While North Queensland will take the field refreshed from a Round 15 bye, the Panthers head to Townsville on the back of a comprehensive, but physically taxing, 30-6 victory over the Roosters.
Penrith haven't lost a game in six weeks, while the Cowboys' last performance – a 45-20 win over the Storm – was arguably their best of the season.
At Queensland Country Bank Stadium this year the Cowboys have won five of seven games and they were winners the last time they faced the Panthers too.