The Eels' September hopes were snuffed out in Friday night's loss to the Roosters, leaving them in 11th place with an 11-12 record.
The ladder-leading Panthers, meanwhile, overcame the absence of Brian To'o, Scott Sorensen and Mitch Kenny to roll past the Titans for their 17th win of the season.
If the premiers can down the Eels on Thursday they will likely secure their third minor premiership in four years, potentially giving coach Ivan Cleary the luxury of being able to rest players from the Round 27 clash with the Cowboys should he choose.