Languishing in last spot on the ladder with one win from five games, the Rabbitohs are averaging just 14 points per game compared to 23.5 per game last season.
They must now try and find a way through a gritty Sharks side that boasts one of the best defences in the NRL and is revitalised after coming off a Round 5 bye.
Mitchell's suspension adds to the woes for the Bunnies, who are also missing star backs Alex Johnston and Campbell Graham to injury, robbing them of much of their potency.