The Dragons are coming off a big win over the Dolphins and will be looking to get another victory against the Titans after coming from behind to get a first-up victory 32-18 in Round 1.
The Titans, coming off a bye, will be fresh to welcome the Red V to the Gold Coast but are also facing some injury concerns in their spine.
Both sides have met on 28 occasions with the Dragons winning the past two clashes in high-scoring fixtures.
A Sunday afternoon scheduling on a sunny Gold Coast only looks set to add to a potential point-scoring try-fest.