The reasons why were unclear but last November he ended a tour early.
He had accused fellow rapper Jay-Z of trying to kill him and walked off stage after announcing he would vote for Donald Trump.
His wife, reality TV star Kim Kardashian, remains on Twitter and has 51m followers.
She has been promoting her and her husband's children's clothing line.
Shortly after West's accounts were deactivated, she tweeted that he had hand drawn a logo for the clothing line.
Fans responded by pleading with her to persuade her husband to return.