Following their 26-18 victory in Game One in Adelaide, the Maroons attacked the game with confidence and enthusiasm in front of a crowd of 52,433 at Suncorp Stadium.
Skipper Daly Cherry-Evans played a starring role, fullback Reece Walsh found a new level after his Origin debut in Game One, while centre Valentine Holmes did much of the damage on the scoreboard with a personal double.
After reverting to the bench before kick-off, prop Lindsay Collins powered through for 135 metres on his way to Player of the Match honours.