Brad Fittler announced his squad for game one on Sunday night with the Penrith halfback retaining his spot, partnered alongside South Sydney pivot Cody Walker.
The in-form Rabbitoh, who will be making his Origin debut, was preferred ahead of last year's series-winning five-eighth James Maloney after Roosters playmaker Luke Keary was ruled out following a heavy head knock in the loss to Newcastle on Friday night.
Apart from Walker, Brisbane's Payne Haas, South Sydney lock Cameron Murray, and Canberra duo Jack Wighton and Nick Cotric are the other uncapped Blues.