After a tense and tight first half it was Daly Cherry-Evans and Lule Brooks who took charge in the second 40 to guide Manly to victory in the first ever premiership match played outside Australia or New Zealand.
Both sides traded sets early before Rabbitohs centre Richie Kennar savoured a special moment with the game's first try in the seventh minute.
It was Cody Walker who put Souths on the attack with a chip and regather before Damien Cook jumped out of dummy half and put Kennar over on the left edge. Latrell Mitchell's conversion made it 6-0 to the Rabbitohs.
