So who is the man asking the questions - and what does he have in store?
High profile
Lester Holt's CV includes major network shows such as Dateline NBC, Today, and his current role as anchor of NBC Nightly News, which attracts millions of viewers every night.
That makes him a national celebrity, and well used to high-stakes TV.
He has already been accused of political bias, when Mr Trump labelled him a Democrat and complained about the "unfair system".
