Rookie Rodda was ruled out of the rest of the season this week to undergo shoulder surgery, and the 77-test veteran Simmons will partner Adam Coleman in the second row.
Hooker and former captain Stephen Moore has been named on the bench and is sure to farewell home fans at Lang Park as he winds down his valedictory season.
Prop Tetera Faulkner has been replaced by Tom Robertson in the reserves, with blindside flanker Ned Hanigan also coming back into the matchday 23 on the bench.
