The Wigan loose forward has failed to recover from the recurrence of his old calf injury he sustained in the early stages of the first Test in Hull on November 21.
England playmaker Sam Tomkins insists his side will cope with the absence of their talismanic captain.
England will announce a replacement captain on Thursday, which is almost certain to be either St George Illawarra's James Graham or Canberra hooker Josh Hodgson.
