He said while he was "concerned" about conditions within the offshore processing network, the Coalition did not want to encourage asylum seekers to risk their lives at sea.
Turnbull told Radio National's Drive program the Federal Government could not afford to take a backwards step on the issue.
"There will be no resettlement of the people on Manus and Nauru in Australia. They will never come to Australia," Turnbull said.
"Now, I know that's tough, we do have a tough border protection policy, you could say it's a harsh policy, but it has worked."