In Port Moresby, the Southern Strikers have a meeting with competition leaders Toti City FC at the PNG Football Stadium.
At the Sir Ignatius Kilage Stadium in Lae will be the encounter between Besta United PNG FC and the struggling Buang FC.
Both matches will start at 3pm.
The match between Madang FC and FC Momase that was scheduled to be played at Laiwaden Oval will be a washout due to the unrest in Madang.
FC Morobe Wawens have the bye this weekend.