Having beaten the Hammers 5-0 in the FA Cup on their previous trip to east London in January, Pep Guardiola's side raced into a three-goal half-time lead thanks to goals from Kevin De Bruyne, David Silva and Jesus, who was preferred in attack to Sergio Aguero.
Yaya Toure added a penalty after the break to cap a dominant performance as West Ham, who handed debuts to Jose Fonte and Robert Snodgrass, struggled to cope with City's pace.
