After two rounds of action in Group D, the 2014 runners-up are staring elimination in the face, having been held to a surprise 1-1 draw by debutants Iceland before capitulating to a 3-0 drubbing at the hands of Croatia.
So much of the pre-tournament talk was whether - in what could be his final World Cup - Messi would finally experience international glory, as great rival Cristiano Ronaldo did with Portugal at Euro 2016.
But a torrid start means Messi's men have it all to do to simply make it to the first knockout stage - La Albiceleste need to defeat Nigeria in St Petersburg and hope Iceland do not manage likewise against already qualified Croatia.
The fall-out from Thursday's damaging loss has been colossal, with legendary 1986 World Cup winner Diego Maradona wading into the mess to criticise head coach Jorge Sampaoli and his methods.
On top of that, reports have surfaced that the Argentina camp staged a mutiny against Sampaoli - talk that was dismissed by the nation's FA president Claudio Tapia as little more than media hype.
"Really [journalists] are the fourth power, do not forget that they are communicators and that with this function that you have to be able to communicate...they transcend, install and distort, they used to talk about teams, how they play, today everything is distorted, but we're going to leave that for after the World Cup," he said.
"They have seen the coaching staff direct the practice, the squad training, they have seen that a lot of what has been said is a lie, we ask for a gesture of support."
— OptaJoe (@OptaJoe) June 21, 2018
As for Nigeria, a draw would be enough as long as Iceland fail to beat Croatia but William Troost-Ekong knows that writing off Messi - who turned 31 on Sunday - could prove a fatal error.
"If Messi wakes up it will be a problem. But we will work for it not to happen," he said.
"It's not the first time we face a team with many good players. We will do our thing and we have chances."
PLAYERS TO WATCH
Nigeria - Ahmed Musa
He has talked a good game, enjoying comparisons made between himself and Messi and suggesting he could be on track to repeat his brace against Iceland. Now it is time for Musa to back that up.
Argentina - Lionel Messi
Who else? He was culpable in the opener against Iceland in missing a penalty and watched on bemused as his goalkeeper and defenders made a royal mess of things against Croatia. Could this be his final outing on the grandest stage?
Photo Getty Images. Caption: Argentina captain Lionel Messi