MENA says the 65-year-old Hisham Barakat died in a Cairo hospital on Monday after undergoing a critical surgery.
He is the top Egyptian official to be assassinated since the ouster of Islamist President Mohammed Morsi two years ago.
Hours earlier, a strong explosion had ripped through Barakat's convoy in the busy upscale eastern suburb of Heliopolis as he was driving to his office in the downtown.
