The rapper's teamed up with the artist Molly Crabapple to make the film, which traces the history of the so-called war.
In just under four minutes, he explains over four decades of American drug policy and incarceration.
The video could be signs of him getting increasingly political, after he recently spoke out against the killing of black men by police officers.
The film speeds up Molly Crabapple's drawings, to whizz through the key points in history.
