With rookie halfback Lachlan Ilias finding his feet and gun No.1 Latrell Mitchell digging deep into his bag of tricks the Rabbitohs turned a 12-6 half-time lead into a comprehensive win.
With so much at stake the Rabbitohs charged out of the blocks with skipper Cameron Murray setting the tone with a try in the ninth minute.
The Roosters then invited their arch-rivals to double the lead with an error from a tap restart and Alex Johnston obliged with the 138th try of his career.