Nadal

After Nadal easily brushed aside Joao Sousa, defending champion Djokovic made light work of Ugo Humbert 6-3 6-2 6-3.

Federer rounded off the day on Centre Court, easily dispatching world number 20 Matteo Berrettini to claim his 99th win at the grand slam.

The eight-time champion will face Kei Nishikori, who got the better of Mikhail Kukushkin 6-3 3-6 6-3 6-4.

Djokovic will go up against David Goffin, while Sam Querrey's 6-4 6-7 (7-9) 7-6 (7-3) 7-6 (7-5) win over compatriot Tennys Sandgren means he will play Nadal.

The world number one has enjoyed a tremendous year, and his 6-3 6-3 6-4 triumph added to his 10th French Open crown secured in June.

It marked the fourth time, and first since 2013, that Nadal has claimed multiple grand slams in a season.

The Spanish great, 31, is back to within three majors of Roger Federer, who has won the most of any man with 19, after clinching a first hard-court grand slam since his 2013 success in New York.

Federer was beaten by Alexander Zverev in the final of the Rogers Cup on Sunday, his limited mobility leading to concerns over his fitness ahead of the US Open.

The Swiss, who has already triumphed at the Australian Open and Wimbledon this year, reported only "aches and pains" after the tournament.

But the 19-time grand slam champion's condition is bad enough for him to pull out of a competition he was won seven times.