EAA spokesman Dick Knapinski says a Piper Malibu went down on a runway at Wittman Regional Airport in Oshkosh shortly before 8 a.m. Wednesday.
Thick black smoke can be seen billowing from the runway. Oshkosh firefighters are at the scene.
The airport has been temporarily closed.
Knapinski says one of the five people has been taken by air to a hospital. He says the other four were taken to hospitals by ambulance.