Waratahs fullback Israel Folau was back to his dominant best, scoring a try in each half, with Nick Phipps, Dean Mumm, Ned Hanigan, Michael Hooper, Damien Fitzpatrick and Bryce Hegarty also crossing for the home side.
Replacement back Jonah Placid scored a brace of tries in the second half for the Rebels, who battled hard but were over-run in the final quarter and slumped to a ninth loss of the season.