The numbers, contained in the monthly civilian casualty report of the Combined Joint Task Force-Operation Inherent Resolve, extend through March.
Inherent Resolve is the US-led assault against the Islamic State that kicked off in August 2014.
"We regret the unintentional loss of civilian lives resulting from Coalition efforts to defeat ISIS in Iraq and Syria and express our deepest sympathies to the families and others affected by these strikes," the task force said in a statement.