The coalition of militias fought 73 days to drive out IS and say they freed 2,000 civilians being used as human shields on the final day.
IS captured Manbij, close to the Turkish border, two years ago.
Roads to Syria's embattled second city, Aleppo, and to the IS capital, Raqqa, pass through the town.
"After the liberation of Manbij, IS members won't be able to freely travel to and from Europe anymore," said Syrian Kurdish leader Salih Muslim.