Not only is Reynolds out, but also forward Kobe Hetherington, five-eighth Tyson Gamble and hooker Corey Paix.
The match would have been the first for Reynolds in Broncos colours as he was rested from the pre-season trials while coach Kevin Walters tried to determine who would partner him in the halves.
In the end it didn't matter and another new recruit, Billy Walters, will play alongside Albert Kelly against the new Rabbitohs pairing of Cody Walker and rookie halfback Lachlan Ilias.