The Dark Blues' faint title hopes were extinguished with defeat to Ireland last week but they will be keen to propel themselves up the table with victory against the tournament's whipping boys after wins against France and England.
Wing Tommy Seymour returns from injury to replace Blair Kinghorn in Rome on Saturday, while centre Nick Grigg makes his first championship start as he takes the place of Pete Horne, whose blunder put Ireland on their way to victory in Dublin.
