Successive defeats by Wales and Australia had already ensured England would be the first hosts to go out of the tournament at the group stage.
Nick Easter, 37, and Jack Nowell scored hat-tricks against a Uruguay side with only four professional players.
Anthony Watson grabbed a well-finished brace, while Henry Slade also crossed.
This was not how it was supposed to end for Stuart Lancaster's men, in a meaningless contest which saw the crowd frequently make their own entertainment with Mexican waves and paper aeroplanes aimed at the pitch.