The Games opening will take place at the Sir John Guise stadium.
The prince is expected to arrive at about 5pm and is to be received by Parliament Speaker Theodore Zurenuoc who is currently the acting Governor General.
Governor General Sir Michael Ogio is attending the coronation celebration of King Tupou VI of Tonga this week.
This is the second time Prince Andrew is officiating at the Pacific Games. He first opened the South Pacific Games which were also held in Papua New Guinea, in 1991.
The officials advised that the program will not be disclosed as yet.