De Villiers smashed his highest ODI score of 176 from 104 balls as South Africa won the second match in Paarl by 104 runs.
South Africa made 353 for six in their 50 overs having been asked to bat, before restricting the visitors to 249 all out in 47.5 overs in their reply.
De Villiers was involved in a third wicket partnership of 136 with Hashim Amla (85 from 92 balls) and 117 for the fourth with JP Duminy (30 from 30 balls) as he thumped 15 fours and seven sixes, making batting look easy on a slow wicket.
