Oprah Winfrey

Winfrey is unequivocally shutting down speculation that she might throw her hat into the political ring.

During a podcast with The Hollywood Reporter, the media mogul was asked about the possibility of challenging President Donald Trump in 2020.

"I will never run for public office," Winfrey said.

In 2015, Trump told ABC's George Stephanopoulos that Oprah would be his dream running mate.

Speaking at the Agnes Scott College commencement ceremony in Georgia on Saturday, Winfrey told the crowd that being "full of herself" propelled her career.

"I used to be afraid of that," she said. Winfrey added that people have criticized her for being "full of herself," but now, Winfrey said she responds with: "Yesss, I am. So full."

Winfrey described "full" as being confident and self-aware -- and she said there's only one way to get there: "You will get nowhere without a spiritual practice."

"I didn't want to take on this role," Winfrey told CNN at New York premiere of her new HBO film "The Immortal Life of Henrietta Lacks." "I was intimidated by it. I was nervous. I just didn't know if I could do it."

Based on a 2010 best-selling book, "Henrietta Lacks" tells the story of a woman being treated for cancer, whose cells were taken without consent in 1951 and used in research for decades -- unbeknownst to her family. Winfrey stars as Henrietta's daughter Deborah Lacks.

The deal joins one of the most famous women in the world with the most prestigious newsmagazine on television.

Winfrey will be a "special contributor," CBS said. This means she'll have several stories on the upcoming season of the newsmagazine. The first story will air sometime in the fall.

CBS declined to comment on the length of Winfrey's contributor deal.

Jeff Fager, the executive producer of the program, said it was "invigorating" discussing the partnership.

"She's a wonderful person full of energy and ideas," he told CNN.

"We feel the difference now. See, now, we are feeling what not having hope feels like," she told Oprah Winfrey in an interview, a clip for which aired on CBS on Friday. "Hope is necessary. It's a necessary concept and Barack didn't just talk about hope because he thought it was just a nice slogan to get votes."

"He and I and so many believe that -- what else do you have if you don't have hope," the first lady added. "What do you give your kids if you can't give them hope?"

Obama said she believes her husband gave Americans something to believe in when challenges arose.

Dieting is no easy feat, but just as the 62-year-old media mogul has done with books, celebrities and daytime television, Winfrey made losing weight look manageable and familiar by bringing fans along for every step of her journey via social media, commercials and Weight Watcher meeting visits. When she was initially invited to invest in the international weight loss company and become a partial owner, Oprah had to try the product before she could sell it.

"In the past several months on Weight Watchers, I have worked with wonderful chefs to make healthier versions of my favorite meals," Winfrey said in a statement. "When people come to my house for lunch or dinner, the number one thing they ask is, 'How is this so delicious and still healthy?' So I decided to answer that question with recipes everyone can enjoy."

Winfrey is also working on her memoir, "The Life You Want," originally scheduled to release this January. Her publisher, Flatiron Books, says it will now publish the cookbook first and push back the memoir release date.