The striker scored twice against Quique Setien's side to become only the second Uruguayan to manage a century of goals in Spain's top flight, after former Atletico Madrid man Diego Forlan, who scored 128 in his career.
Lionel Messi was also on target twice after Ivan Rakitic had put the league leaders ahead just before the hour mark to secure a win that stretches their lead at the top to 11 points.
The match saw Messi reach two more personal milestones of his own, the Argentina star having assisted a goal in five LaLiga matches in a row for the first time in his career.
