Thursday night's 2016 NRL season opener between the Broncos and the Eels will be McGuire's first NRL game since rupturing his Achilles almost nine months ago.
The costly injury occurred in Brisbane's Round 16 clash against Newcastle and McGuire was sorely missed during the Broncos' run to the grand final.
2015 was shaping as McGuire's best year as he made his long awaited State of Origin debut for Queensland.
Playing in the opening two games of the series, McGuire was set to feature in the third and deciding fixture before his season was cruelly cut short.