Steven Spielberg will also be back to direct, having headed up all the previous four films.
"Indiana Jones is one of the greatest heroes in cinematic history, and we can't wait to bring him back to the screen in 2019," said Alan Horn, chairman of The Walt Disney Studios.
"It's rare to have such a perfect combination of director, producers, actor and role, and we couldn't be more excited to embark on this adventure with Harrison and Steven."
Kathleen Kennedy and Frank Marshall will produce the film, which is slated to hit the big screen on July 19, 2019.
