They will play seven matches in USA against some of the US university teams, including last year's national champions.
The team had their first friendly against the US U-20 women's team during the Tri-Nations match in May in Port Moresby where US defeated them 10-0.
They also travelled to Korea for a friendly in June and hope to have more friendly matches after the US trip within the region to get them ready.
PNG U-20 women's coach Lisa Cole said over the last 6 months, the players have been training hard to prepare themselves for this challenge.