The lead was extended further by a try in the 21st minute off a brilliant dummy half run by Damien Cook with support from Maloney to put James Tedesco between the sticks.
The match was shaken up with a hit from Maroons captain Greg Inglis from an offside position, costing them a penalty.
An Intercept by Holmes on a long pass by Maloney close to the Maroons try line saw Holmes run the length of the field to register the Maroons first points in the 28th minute, later converting his own try.
They went into the sheds at half time 8-6 in favor of the Blues.
A tight struggle in front of a crowd of 87 953 at the Melbourne Cricket Ground it was neck to neck in the second half.
A perfect kick from Ben Hunt put Maroons winger, Dame Gegai over the try line two minutes into the second half. Getting his 8th try in the State of Origin Series.
23 meters out from the posts, Homes successfully converted the try, putting the Queenslanders in the lead 12-8.
A try in the 47th minute to Latrell Mitchell off a James Tedesco pass saw the blues level with Queensland 12 all.
A break by James Tedesco put NSW in good field position for Tom Trbojevic to score off a Maloney bomb in the corner. With the conversion by Maloney, the blues led 18-12 in the 52nd min.
Nathan Cleary was the victim to another powerful hit up by Inglis before Maloney put the ball over the side line, giving breathing space for both teams.
With just under 12 minutes of the game remaining, Tedesco broke the defense line of the Queenslanders, finding Josh Addo-Carr on the left side of the field, extending the blues margin 22 -12.
The blues who has 11 players in debut proved the better team over a slightly more experienced maroons line up.
A 40-20 kick in the 74th minutes gave the maroons an opportunity to close the 10 point margin however the ball found the dead ball line off the boot of Michael Morgan 2 tackles into their set later on.
A no try to Mitchell with under 4 minutes to go saw another attempt by Addo-Carr two minutes later, as scores remain unchanged into full time.
Picture courtesy of State of Origin Facebook page