The high-tension cable fell on a crowded shack showing the Europa League quarter-final against Anderlecht in the southern city of Calabar.
At least 30 people were taken to hospital by local ambulances and police who arrived quickly at the scene.
English football has a large and passionate following in Nigeria.
Eyewitnesses describe hearing a loud explosion from an electrical transformer which caused the cable to fall.
An eyewitness told the BBC he had counted at least 16 bodies, including children, at the scene of the accident.
It has been reported that scores of fans managed to escape.
Manchester United has responded by tweeting its condolences to the victims and their families.