Currently touring with his band Hollywood Vampires, the 54-year-old seemed happy to sign autographs and take photographs with fans in footage posted online.
Depp sported a baseball cap that said 'FUGLY' and dark sunglasses in the images, and appeared "sick" to many social media users.
This is the second time the Pirates of the Caribbean star has recently triggered people into commenting on how thin and pale he looks, the first being in Russia a few days earlier.
"Johnny Depp is sick. Just look at this picture of him," said Twitter user Bryan700.
"I think my hero looks ill," said a Facebook user.