The Opposition needs 56 votes to topple the O'Neill - Dion Government when Parliament sits at 10am.
The motion for the Vote of No-Confidence will be the only business in this special session directed by the Supreme Court.
The reading of the VONC was done seven days ago, and this morning the 108 MPs will vote.
The other three seats in the House of representatives are vacant.
An optimistic Opposition Leader Don Polye has been keeping the numbers game close to his chest.
With only 20 MPs in the alternative government camp, Polye has repeated time and time again that he also has support in the Government side to change the prime minister.
Meanwhile, Prime Minister Peter O'Neill said the coalition government is intact with 81 confirmed MPs and will complete its term in office.