The boat, carrying four females and two males, was returning to Wewak on Saturday (March 4) after their betelnut sales run to Lorengau.
A Manus woman is amongst those missing while the rest are from Tarawai Island, Murik and Maprik in the East Sepik Province.
Acting provincial police commander, Senior Inspector David Yapu, told Loop PNG the missing boat was reported on Friday 10 March after it did not reach Wewak.