Carrie-Anne Moss will also return as Trinity, with Lana Wachowski coming back as director and co-writer after creating the franchise with her sister Lilly.
"Many of the ideas Lilly and I explored 20 years ago about our reality are even more relevant now," Wachowski said in a statement published by Variety.
"I'm very happy to have these characters back in my life and grateful for another chance to work with my brilliant friends."
Lana wrote the new film's script along with sci-fi novelists Aleksandar Hemon and David Mitchell.
