Both sides are coming off Magic Round defeats, a third in four weeks for Manly, so the stakes will be high and CommBank Stadium is sure to be buzzing.
Their previous meeting in round 22 last year resulted in a 56-10 cakewalk for the Sea Eagles as Reuben Garrick piled on 28 points, just two shy of Ron Rowles' record of 30 set way back in 1954.
A repeat of that sort of scoreline is unlikely but the Eels are sure to be on high alert as they confront a Manly backline packed with threats and desperate to make a statement after being held scoreless in Magic Round.