Ashkan Dejagah put the home side ahead from the penalty spot after ten minutes, as Asia's top ranked team took a commanding 4-0 lead into half-time at the Azadi Stadium in Tehran.
Mehdi Taremi and Sardar Azmoun bagged two goals each, with substitute Mehdi Torabi capping a clinical display with a final goal minutes from the end.
Defeat means the Mateo relinquish top spot in Group D to their next opponents, Oman, who beat Turkmenistan 3-1.
