Wilder, who has promised to face Anthony Joshua if he beats Joseph Parker, will defend his world title belt for a seventh time when he takes on Ortiz at the Barclays Centre, New York, on March 3, live on Sky Sports.
The two fighters head into this bout undefeated, and Ortiz is confident he can knock out the 'Bronze Bomber', insisting he is the toughest opponent Wilder has ever come up against.
"He's talking too much. He's going to have to back that up in the ring," said Ortiz. "He says he's going to kill 'King Kong'.