Boyce suffered a seizure as a result of an ongoing medical problem, his family said.
"It is with a profoundly heavy heart that we report that this morning we lost Cameron," a family spokesperson said.
"He passed away in his sleep due to a seizure which was a result of an ongoing medical condition for which he was being treated.
"The world is now undoubtedly without one of its brightest lights, but his spirit will live on through the kindness and compassion of all who knew and loved him. We are utterly heartbroken and ask for privacy during this immensely difficult time as we grieve the loss of our precious son and brother."
Boyce made his first film at the age of 9 in the horror Mirrors. He then featured in the thriller Eagle Eye, before finding fame in Disney Channel franchise Descendants and kids TV show, Jessie.
He also played Keithie Feder, son of Adam Sandler's character Leonard Feder, in the comedy Grown Ups.